Cancer, Senescence, and Aging: Translation from Basic Research to Clinics
نویسندگان
چکیده
1Oncoloǵıa y Patoloǵıa Grupo, Vall d’Hebron Institut de Recerca, 08035 Barcelona, Spain 2Unitat de Recerca Biomédica, Instituto de Biomedicina de Sevilla, 41013 Sevilla, Spain 3Genomic Stability Laboratory, Leibniz Institute for Age Research, 07745 Jena, Germany 4Genome High-Throughput Sequencing Laboratory, Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
منابع مشابه
Looking for immortality: Review of phytotherapy for stem cell senescence
Objective(s): In this paper, we discussed natural agents with protective effects against stem cell senescence. Different complications have been observed due to stem cell senescence and the most important of them is “Aging”. Senescent cells have not normal function and their secretary inflammatory factors induce chronic inflammation in body which causes different patho...
متن کاملSeeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells.
Telomerase activation is a hallmark of cancer. Advancement of telomerase as a therapeutic drug target has paved the way for translational opportunities in the related fields of senescence and cancer stem cells. Here, lessons may be learnt that can be applied to drug discovery, particularly with regard to the need to appreciate the relationships between telomerase, senescence and cancer stem cel...
متن کاملتجربه آغاز حس سالمندی: یک مطالعه کیفی
Background and purpose: Different sources have provided various descriptions on the onset of senescence and its associated factors. Any person may become senile at a different age. The objective of the present study was to explore the feelings related to the onset of aging and factors influencing it based on old women’s experience. Materials and methods: This study used a qualitative approach ...
متن کاملAssessing cell and organ senescence biomarkers.
A major goal in cancer and aging research is to discriminate the biochemical modifications that happen locally that could account for the healthiness or malignancy of tissues. Senescence is one general antiproliferative cellular process that acts as a strong barrier for cancer progression, playing a crucial role in aging. Here, we focus on the current methods to assess cellular senescence, disc...
متن کاملCathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence.
Induction of premature senescence may be a promising strategy for cancer treatment. However, biomarkers for senescent cancer cells are lacking. To identify such biomarkers, we performed comparative proteomic analysis of MCF7 human breast cancer cells undergoing cellular senescence in response to ionizing radiation (IR). IR-induced senescence was associated with up-regulation of cathepsin D (CD)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2011 شماره
صفحات -
تاریخ انتشار 2011